Unisom Review


Unisom is a line of sleep aids approved by the FDA. They contain proven active ingredients that have been used in sleep aids for over 20 years.

They are sold in reputable drugstores and are even on the bestseller list of Drugstore.com. Hundreds of people have overcome restless nights thanks to Unisom.

Since Unisom works for so many people, find out which Unisom product can best help you achieve a more restful night’s sleep.

Unisom PM Pain SleepCaps

Unisom PM Pain includes a pain reliever and a sleep aid to help those who can’t sleep due to aches and pains. Unisom PM Pain’s key ingredients include diphenyhydramine HCI and acetaminophen.

Diphenhydramine HCl is an antihistamine approved by the FDA as a sleep aid. [1]

Unisom PM Pain SleepCaps contain 50 mg diphenhydramine HCl, the accepted effective dose. Do not take more than the recommended dose, as it could lead to side effects. [2]

Common side effects of overdose include incoherence, blurred vision, delirium, diarrhea, stomach pain, agitation, and lack of sweat. [3]

Acetaminophen is a common pain reliever that decreases inflammation. If you are suffering from low-grade fever, muscle ache, arthritis, headache or the common cold, acetaminophen can relieve these symptoms. [4]

Unisom PM Pain SleepCaps contains 325 mg acetaminophen. This dose is considered effective by the FDA for minor aches and pains. If you still experience pain after taking Unisom SleepCaps, consult your doctor. Mixing sleep aids with pain medications can lead to serious side effects. [2]

Unisom SleepGels

Unisom SleepGels contain the same dose of diphenhydramine HCl as the SleepCaps:
50 mg. [5]

SleepGels encapsulate the active medicine in a soft gel container. The containers are usually larger than the same medicine in tablet form, but the smoothness of the gel makes them easier to swallow. Some people prefer gel caps because they are more attractive, others because they have no taste. [6]

Absorption of active ingredients is the same in soft gels and tablets. [7]

Unisom SleepMelts

Unisom SleepMelts are essentially the same as Unisom SleepGels and Unisom PM Pain SleepCaps. The main active ingredient is diphenhydramine HCl. However, each tablet contains 25 mg, which means you have to take two to get the effective dose. [8]

The tablets dissolve on the tongue and are flavored with a cherry taste. No swallowing is required, which is a godsend for those who have difficulty swallowing pills.

Unisom SleepTabs

Unisom SleepTabs are the only product with a different active ingredient: doxylamine succinate.

Doxylamine succinate is an antihistamine approved by the FDA to be used as a sleep aid. [9]

Unisom SleepTabs contains 25 mg doxylamine succinate per tablet, which is the standard accepted dosage. [10]

Do not take more than the recommended dosage, as it can cause side effects. Side effects include headache, dizziness, upset stomach, constipation, blurred vision, and irritability. [11]

If difficulty sleeping continues for 2 weeks while taking Unisom SleepTabs, this could be a sign of a more serious condition. Consult your physician. [12]

Consumer Reviews

Unisom products are extensively and positively reviewed by hundreds of customers on third-party sites, which is comforting. Although the products may not work for everyone, they have been thoroughly vetted by the public.

Reviews of Unisom PM Pain SleepCaps

Consumers generally get better sleep using Unisom PM Pain SleepCaps. The only negative review I could find was by someone with epilepsy whose condition was exacerbated by the product.

Reviews of Unisom SleepGels

While some reviewers reported hallucinations or vivid dreams, most achieved restful sleep while taking Unisom SleepGels. Consumers liked the fast-acting aspect of the SleepGels. A few consumers felt groggy the next morning, but not all.

Reviews of Unisom SleepMelts

Most reviewers chose Unisom SleepMelts because they had difficulty swallowing pills. Consumers are divided about the taste of the tablets; some thought they tasted pretty good while others experienced an overwhelming gag reflex. Consumers found the SleepMelts to be less potent than other sleep aids, which means they would be a better choice for people with mild sleeping problems or people who are sensitive to sleep aid medications.

Reviews of Unisom SleepTabs

Consumers overwhelmingly prefer Unisom SleepTabs to the other Unisom products. The SleepTabs are a best seller on Drugstore.com. However, more reviewers reported grogginess the morning after taking the SleepTabs than with any other Unisom product.

Since Unisom SleepTabs includes doxylamine succinate as its main ingredient, some people prefer it to other sleep aids that use different active ingredients. Others report it doesn’t work for them. However, there were very few reported side effects.


You can go to any online or brick and mortar pharmacy to buy Unisom sleep aids. Prices vary from store to store, but they are roughly as follows:

• Unisom PM Pain SleepCaps: $9 (30 capsules)
• Unisom SleepGels: $15 (60 soft gels)
• Unisom SleepMelts: $7 (24 tablets)
• Unisom SleepTabs: $10 (48 tablets)

Unisom SleepTabs are the cheapest option. Unisom PM Pain SleepCaps are the most expensive (although they do contain more active ingredients, so they could still be a good deal).

The Bottom Line

Unisom includes a variety of sleep aid products that have received nearly universally positive reviews and are approved by the FDA. The prices are reasonable, and there is little risk of becoming dependent.

Unisom is a reliable brand that produces reliable over-the-counter sleep aids. While not every sleep aid will work for everyone, Unisom includes products with two different active ingredients, so one product might work better than the other.


[1] “Diphenhydramine HCl Oral.” WebMD. 2013. Available from: http://www.webmd.com/drugs/drug-1428-Diphenhydramine+HCl+Oral.aspx?drugid=1428&drugname=Diphenhydramine+HCl+Or al

[2] “Unisom PM Pain Nighttime Sleep Aid and Pain Reliever (acetaminophen and diphenhydramine hydrochloride) tablet.” DailyMed. Aug 2010. Available from: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=451daeeb-88a9-44b1-9a2d-1ff0b0ec41cb

[3] “Diphenhydramine Overdose.” Medline Plus. 2013. Available from: http://www.nlm.nih.gov/medlineplus/ency/article/002636.htm

[4] “Acetaminophen.” Drugs.com. 2013. Available from: http://www.drugs.com/acetaminophen.html

[5] “Unisom SleepGels Nighttime Sleep-Aid (diphenhydramine hcl) capsule, liquid filled.” DailyMed. Mar 2012. Available from: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=17383d22-91cc-4d9e-a0b8-3f7d9a18af83

[6] Rockwell, Rich. “Vitamin Soft Gels and Tablets Differences.” LiveStrong.com. 1 Sep 2011. Available from: http://www.livestrong.com/article/528855-vitamin-soft-gels-and-tablets-differences/

[7] “No significant difference in absorption between tablet and softgel capsule forms of folic acid.” News Medical. 17 May 2012. Available from: http://www.news-medical.net/news/20120517/No-significant-differences-in-absorption-between-tablet-and-softgel-capsule-forms-of-folic-acid.aspx

[8] “Unisom SleepMelts (diphenhydramine hydrochloride) tablet, chewable.” DailyMed. Jan 2011. Available from: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9105f4f1-7f94-408d-a025-83afb68dc9f0

[9] “Unisom SleepTabs (doxylamine succinate) tablet.” DailyMed. Jun 2011. Available from: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d5e3015c-49ae-4288-a78f-17a141f26817

[10] Prater, Alicia. “Side Effects and Warnings of Doxylamine Succinate.” LiveStrong.com. 29 Mar 2011. Available from: http://www.livestrong.com/article/236509-side-effects-and-warnings-of-doxylamine-succinate/

[11] “Doxylamine Succinate Oral.” WebMD. 2013. Available from: http://www.webmd.com/drugs/drug-14124-doxylamine+succinate++sleep++oral.aspx?drugid=14124&drugname=doxylamine+succinate++sleep++oral

[12] “Doxylamine Succinate.” Drugs.com. 2013. Available from: http://www.drugs.com/monograph/doxylamine-succinate.html

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